The best layout depends very much on what you want to use it for ...
From the above we can see that no one layout will be perfect for every use.
However we can still try to compare layouts, and use the results as a guide to picking one which is best for our needs.
There are different ways of measuring keyboard effectiveness, and each person tackling the problem takes a slightly different approach, leading to different results. It depends very much on WHAT you measure, based on WHICH inputs.
For example, we could measure
These factors are also tied up in the physical layout of the keyboard, of which in recent times there have been a veritable explosion away from the standard ANSI/ISO layouts.
So we have analysed the results from some popular layout analyzers, of which only 1 set is now available, others will be added in due course. You can interrogate the database and do your own comparisons for different categories etc. on the pages below, or you can view the Current Best Keyboard Layouts.